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Having been the previous owner of Leon's 500L, I can testify that its a go-er for safaris - except....you need a VERY sturdy mount, a Kirk or similar that can be attached almost anywhere on a vehicle. Its definately not hand-holdable for more than a few seconds. These mounts typically run $300-$1000 depending on features. The 100-400 is IS enabled but is not very sharp compared to other L glass. I've seen better results with a 70-200 f2.8 IS and teleconverter. Though thats getting a bit pricey.
A good compromise is the 300 f4L IS or the 400 f5.6L IS and shooting in RAW to capture more detail. You can then enlarge the image without much loss of detail.
The downside is that the autofocus is a bit dodgy at this apeture and you need good light and/or a slow moving target. There are quite a few on the second-hand market so it shouldn't break the bank.
Hope this helps. Have a great trip and watch out for the Hippos.
PJH
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