"Active" USB cables are smoke and mirrors, they more often than not lead to issues. The USB 3.x standards don't specify a maximum length, instead relying on the fact that the controller will fall back to USB 2.0 specs when the USB 3 specs can't be met.
What this means is you end up expecting 1 thing and achieving another. USB2 is limited to 400ish Mbit/sec which is a long way short of 3.x which should be around 5 Gbit/sec. When you start trying to cram guiding pulses, guiding images and astro imaging data down that limited bandwidth it will inevitably cause issues.
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