Something like M42, you would take shorter subs and then stack them. That would help to prevent blowout of the Trapezium.
The attached image of 47 Tuc is a stack of 10x 5-second subs at iso1600. I probably could have brought it down to iso1000 or 800 for less noise, but you can see that the centre isn't blown out too badly at all. I can zoom in on the original sized image, and pick out a good number specific stars.
For me, the bigger issue is getting good focus with the DSLR, initially.
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