Couple of things.
1. don't forget to take darks of the same length and subtract those away.
2. even cooled cameras have lots of noise in a single image. You need to stack lots of frames to remove noise and increase signal.
3. What camera are you using? Some cameras are more capable than others. If you are using a camera 3 years old or under that, then you can use ISO1600 but you still need to do darks and stacking to get a smooth shot.
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