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They could be binning artefacts, your best way to see would be to take a dozen or so bias' and stack them, see if they remain.
From the 1x1 it looks like you have done tilt. The smaller the pixels are the more readily they become observable (I think).
What is a QHY22 worth these days? I have been considering making the change from my QHY9 for the much larger QE in Ha (30% vs 60%).
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