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The first thing I would try would be a direct connection to your PC to eliminate the two hubs (Your external hub and the one in the 1600)
I have been using a 290MM mini almost entirely trouble free for about a year now. The only issue I have had was recently where it appears that moisture caused some corrosion or a dendrite in the USB connection, as soon as it was plugged in, everything else on the hub dropped offline.
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