Fascinating topic,
given all seriously large professional observatories are mirrors then the questions already answered, once you get so big that atmosphere plays a part then adaptive optics and computer tricks are required so it's no longer just the scope.
Given ground based observatories are now producing Hubble esq images, anythings possible, just depends how deep your pockets are.
HOWEVER for me I have had both reflectors and refractors, for simplicity of use I prefer a refractor, no collimating, no reapplying coatings, minimal flexure ..... Grab and go then enjoy.
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