You won't be guiding on the galaxy, you'll be guiding of a nearby star in the FOV. With my ASI120MM I take 100-500ms exposures, which in PHD2 are then stacked as an average of 5-10 frames.
Guide stars will be somewhat misshapen if you are using a focal reducer, because they will be capturing light away from the ideal focal plane. It should not be a major problem for guiding, however.
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