The surface brightness of NGC 300 varies from ~18-19 Mag/square arcsec near the centre to ~24+ at 11 arcmin from the centre. If the sky background is 18.5, as it is from my suburban Melbourne location, then this object is going to be extremely difficult.
From a good dark sky site (SQL 21.4) with a 10" f/3.6 scope a reasonable image is gettable. The image included here is 80min L binned X1 and 3 hours RGB binned X2; camera Moravian G2-8300.
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