Best to stand on the site where you are going to build your observatory and look at the sky that is exposed in different directions. There are a lot of targets in the Large Magellanic Cloud that you would want to be able to image as often as possible.
Also consider the predominant wind direction. It would be good to be able to roll your roof in such a way as to shelter from that wind. If you live in a windy area that could give you an extra 20 nights or more of imaging time where the wind is neutralised.
Greg.
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