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The biggest wrinkle I have found in imaging near the pole is mosaics, usually I have found that camera clearance is better than nearly anywhere else and as others have indicated, guiding is generally easier.
Some mosaic planners fall to bits near the pole as your "Apparent" camera angle changes significantly as you move around in RA and the closer you are to the pole the worse it gets, you can end up with some "unexpected" results.
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