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I would ordinarily take a test shot and then look at the pixel brightness of the area I'm wanting to capture. I can then work out the multiple I need to achieve the pixel brightness I'm happy with (compromised with exposure time length) and so that multiple times by my test exposure time gives me how long to do each exposure for.
In reality I do all that in my head with a healthy dose of gut feel thrown in.
I'm not sure which nebula in particular you're referring to, to be able to comment about FOV sorry.
Roger.
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