Hi Scott
You're probably better off with 7x50 or 10x50 binocs for Andromeda.
The whole thing is about 4 times the size of the full moon.
The bright central core would probably appear as a big hazy smudge at lower power in your 4SE.
This time of the year other bright(er) galaxies you might see from a nice dark location include M104 (Sombrero) or some of the Leo or Virgo galaxies.
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