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Sampling at 0.49"/px is going to be pretty tough. Going by the 3x rule of thumb, that means the total of your guiding error, optics and seeing would want to be about 1.5" for you to be appropriately sampled. Not undoable, but you need a good mount and good seeing. Even with a reducer bringing it down to 0.61"/px it's not going to be easy. Either you need low expectations, or a seriously good mount and good skies.
I also would not bin the ASI 1600. It drops back to 10 bit mode and according to the manufacturer, the only real benefit you get to binning the 1600 is reducing the file size.
If you dither and use drizzle integration, you can "get back" some of that lost resolution on one of those rare nights that everything falls into place and you end up undersampled.
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