Simon,
Go for it! Peter made it quite loud and clear in his post regarding the uses for this camera;
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...On the sampling side, putting this chip on a, say 10"RC would not be a great choice....Where the ST8300 may be very cool is with camera lenses...
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I don't disagree with the above statements. The 8300 would certainly excel in short focal length work given its small pixel size. Coupling it to a 200mm lens would be remarkable. Clearly its best to have oversampled data than undersampled, but at the same time imagers need to be realistic. The arcsec/pixel combination is one of many factors that impact image resolution. Regardless of what telescope you match this chip with, you'll need to consider your approach to imaging.
Theo's experience is the extreme given the long focal length and sampling his set up delivers. Binning would assist with sampling, but would also result in pixels reaching saturation faster. Using the 8300 with short to medium focal lengths and alternating exposure times from what I've seen to date can deliver aesthetic results. Numerous imagers are happy with the camera. It depends on what you're looking for.