High resolution comes down to monitoring. Being able to see on the screen at the same time: PHD guiding graph, guide star profile, EQMod, the most recent image downloaded, and the progress through the capture is invaluable. It may be headless, but it's not hands off
Unfortunately at present this is all actions from different overlapping apps for me. I'm aware that programs like Sequence Generator or Maxim will distill this down to a far more compact form with the most recent image in the centre, and then guide statistics and graphs telescope orientation etc in a decent format on the side bar.
Ultimately though I don't appear to be limited by CPU or Network bandwidth so why wouldn't you want use the highest resolution you can afford?