As much as I like my mono ASI1600, it doesn't seem to make a lot of sense for comet hunting.
DSOs are a sure thing, long (=60-90s) exposures on a target that is only moving at sidereal rate.
Planetary too, where the frame rates are so high that short but separate R, G and B sequences can be pieced together and derotated.
Comets...sit somewhere in between
prolly want the longer exposures as they can be faint, but that makes piecing the colour channels together more challenging because of any motion.
OSC might be the balanced solution...
But check out the amp glow and challenges with calibrating the 183. Given your focal length, I can't imagine that the 1600 is at a disadvantage, and calibrates neatly every time.