I do not think the relative fls matter too much either but you should consider the image scale of each camera. While it is true that PHD (and others) will perfom sub-pixel guiding if you are guiding at 10"/pixel or worse you will have trouble if you are imaging at 1" or better. Bear in mind you want your corrections to be +/- 2 pixels or less on the imaging sensor for visually acceptable results.
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