Ricky, I'm not up with mono cameras so I can't really comment with what settings you used for these shots. By the amount of noise showing it looks like you've had to stretch these images a fair bit to reveal any detail. Your focus looks fine to me and the marks I can see look like dust spots on your sensor. I have that pitted look in my refractor after it suffered a severe change in temperature from the cold winter air into a warm car. Condensation formed on the glass elements and it took several days to evaporate. I did not clean it and it doesn't seem to have affected the image quality at all. I would not be cleaning the optics.
Do you use flats? Was there any cloud during your exposures? Were you in a light polluted location when taking these shots?. There can be many reasons and variables why these didn't turn out the way they have in the past. Someone with a mono camera may be able to give you more answers.
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