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Alistair,
The issue with OSC is the Bayer matrix filter...obviously the pixel size is important for good sampling, but depending on the filters and objects being observed, the matrix does reduce the "resolution" somewhere around 60%.
This is where mono CCD's win....
The well depth (and the readout - 16 v's 32 bit) are also issues....
but the starting point is good sampling (Nyquist >2), low read/dark noise and maximum QE - where you need it....
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