I've used a Canon 5DII on my ED 80 and skywatcher reducer (specific to that model) with the special wide t mount and can't recall seeing any vignetting.
FWIW the dedicated Skywatcher reducer screws on to the standard SW dual speed focuser after removing and enables the widest possible imaging path. I can't see any reason for nikon to be any different provided the same focuser, reducer and tmount are used.
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