Hi Frank,
I think you main "general" issue with OAG is going to be FOV of the guide camera at the focal length you are using and then being able to find a guide star within that FOV. It may mean you sacrifice your image presentation/FOV to find a guide star with an OAG.
If you chose a guide scope then differential flexure is your main issue to deal with, this can be overcome though with good mechanics.
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