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I have the 100-400L, and have had Dennis' 400L on my camera for about 2mins max. The 400L definitely focuses faster - very fast. It's light and smaller than I imagined. Quite impressed with it actually.
That being said, the 100-400L is more compact for travel. Might be heavier, but not prohibitively heavy. I like the versatility in focal length and the IS.
If I had my time again and had to buy one, I honestly am not sure about which one I'd get. May lean towards the 400L? But that's probably because I now have the 135L and 180L and don't really need the lower end of the focal range of the 100-400L.
However considering travel, compactness and versatility being high on my priorities, I'd go the 100-400L.
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