I remember reading on the qhyccd forums that the QHY8 only uses 27000 of the possible 65000 possible tones in 16bit due to the sony sensors well depth.
It is also recommended to have a flat brightness value of 1/3 of the dynamic range. So this means you want your flats to read an average ADU of 9000.
I'll try to find the thread in question.
Also do you use bias frames?
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